The best area to stay in Rio Grande, Zacatecas, is the town center, particularly around the Jardin Principal (main garden) and the surrounding blocks.
This central area is the heart of Rio Grande, characterized by its traditional Mexican architecture, including the prominent Parroquia de Nuestra Señora de Guadalupe church. The streets here are generally walkable and feature a selection of local shops, eateries, and services. The Jardin Principal itself is a well-maintained public space where locals gather, offering a pleasant spot for a stroll or to sit and observe daily life.
For travelers seeking an authentic local experience, staying in the town center is ideal. You'll be within easy reach of the main church, the municipal market, and various local businesses, allowing you to experience the daily rhythm of the town directly.